Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007030)
Formula
SVG example
4'-demethylation
Reactant Hesperetin Product Eriodictyol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - 4'-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007031 Hesperetin Hesperetin 3p-O-Glucuronide Conjugation - Glucuronidation Hesperetin [1], [2]
MR007032 Hesperetin Hesperetin 7-O-glucuronide Conjugation - Glucuronidation Hesperetin [1], [2]
MR004485 Hesperetin 3-(3'-Hydroxy-4'-methoxyphenyl)-2-propionic acid Unclear VS-12343 [3]
MR003858 Hesperetin Hesperetin-sulfo-O-glucuronide Unclear BRN-0183227 [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003839 BE-14348A Eriodictyol Oxidation - Hydrolyzationn BE-14348A [5]
MR004320 Naringenin Eriodictyol Oxidation - Hydrolyzationn Naringin [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003840 Eriodictyol Hesperetin Conjugation - Methylationn BE-14348A [5]
MR004321 Eriodictyol Hesperetin Conjugation - Methylationn Naringin [6]
References
1 BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification
2 Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation
3 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium
4 Stratification of Volunteers According to Flavanone Metabolite Excretion and Phase II Metabolism Profile after Single Doses of 'Pera' Orange and 'Moro' Blood Orange Juices
5 Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species
6 Microbial Metabolism of Naringin and the Impact on Antioxidant Capacity

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.