Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007165)
Formula	CYP3A4 ... 6-methylhydroxylation
	Reactant	Etoricoxib	Product	6-Hydroxymethyletoricoxib
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)				DME Info
	Cytochrome P450 2C9 (CYP2C9)				DME Info
	Cytochrome P450 2D6 (CYP2D6)				DME Info
	Cytochrome P450 1A2 (CYP1A2)				DME Info
Metabolic Type	Other reaction - 6-methylhydroxylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR007163	Etoricoxib	Etoricoxib 1'-N'-oxide	Oxidation - 1-N-oxidation	Etoricoxib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR007166	6-Hydroxymethyletoricoxib	6-Carboxy-etoricoxib	Oxidation - Oxidationn	Etoricoxib	[1]
MR007167	6-Hydroxymethyletoricoxib	6-Hydroxymethyletoricoxib glucuronide	Conjugation - Glucuronidation	Etoricoxib	[1]
MR007168	6-Hydroxymethyletoricoxib	6-Hydroxymethyletoricoxib-1'-N'-oxide	Oxidation - 1-N-oxidation	Etoricoxib	[1]

References
1	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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