Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007166)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant 6-Hydroxymethyletoricoxib Product 6-Carboxy-etoricoxib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007165 Etoricoxib 6-Hydroxymethyletoricoxib Other reaction - 6-methylhydroxylation Etoricoxib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007167 6-Hydroxymethyletoricoxib 6-Hydroxymethyletoricoxib glucuronide Conjugation - Glucuronidation Etoricoxib [1]
MR007168 6-Hydroxymethyletoricoxib 6-Hydroxymethyletoricoxib-1'-N'-oxide Oxidation - 1-N-oxidation Etoricoxib [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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