Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007173)
Formula Reactant Methamphetamine Product p-Hydroxymethamphetamine
Reactant Info Product Info
Metabolic Type Oxidation - p-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005724 Benzphetamine MethAmphetamine Unclear Benzphetamine [1]
MR007169 Famprofazone Methamphetamine Oxidation - N-dealkylation Famprofazone [2]
MR010841 Selegiline Methamphetamine Unclear - Unclear Selegiline [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007170 Methamphetamine Amphetamine Oxidation - N-demethylation Famprofazone [2]
MR010842 Methamphetamine Amphetamine Unclear - Unclear Selegiline [3]
MR007175 Methamphetamine Ephedrine Pseudoephedrine Oxidation - eta-hydroxylation Famprofazone [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009991 Metamfetamine p-hydroxymethamphetamine Unclear - Unclear Metamfetamine [4], [5]
MR010007 Methamphetamine hydrochloride p-hydroxymethamphetamine Unclear - Unclear Methamphetamine hydrochloride [4], [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009992 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [6]
MR010008 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [6]
MR007174 p-Hydroxymethamphetamine p-Hydroxyamphetamine Oxidation - N-demethylation Famprofazone [2]
References
1 DrugBank(Pharmacology-Metabolism):Benzphetamine
2 Identification of new urinary metabolites of famprofazone in humans
3 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations
4 Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
5 Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia
6 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat

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