Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010007)
Formula Reactant Methamphetamine hydrochloride Product p-hydroxymethamphetamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010000 Methamphetamine hydrochloride Amphetamine Unclear - Unclear Methamphetamine hydrochloride [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009991 Metamfetamine p-hydroxymethamphetamine Unclear - Unclear Metamfetamine [3], [4]
MR007173 Methamphetamine p-Hydroxymethamphetamine Oxidation - p-hydroxylation Famprofazone [5]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009992 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Metamfetamine [6]
MR010008 P-hydroxymethamphetamine 4-Hydroxyamphetamine Unclear - Unclear Methamphetamine hydrochloride [6]
MR007174 p-Hydroxymethamphetamine p-Hydroxyamphetamine Oxidation - N-demethylation Famprofazone [5]
References
1 Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
2 Drugs of abuse in a non-conventional sample; detection of methamphetamine and its main metabolite, amphetamine in abusers' clothes by HPLC with UV and fluorescence detection
3 Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
4 Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia
5 Identification of new urinary metabolites of famprofazone in humans
6 Metabolism of ( 14 C)methamphetamine in man, the guinea pig and the rat

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