Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007417)
Formula	CYP2D6 O-demethylation
	Reactant	CP-122721	Product	CP-125611
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 2D6 (CYP2D6)				DME Info
Metabolic Type	Oxidation - O-demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR007423	CP-122721	CP-677623	Unclear	CP-122721	[1], [2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR007421	CP-125611	CP-919230	Oxidation - N-dealkylation	CP-122721	[1], [2]
MR007418	CP-125611	Quinone	Unclear	CP-122721	[1], [2]

References
1	In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49.
2	Metabolism, pharmacokinetics, and excretion of the substance P receptor antagonist CP-122,721 in humans: structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography-tandem mass spectrometry and NMR spectroscopy

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