Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007421)
Formula
SVG example
N-dealkylation
Reactant CP-125611 Product CP-919230
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007417 CP-122721 CP-125611 Oxidation - O-demethylation CP-122721 [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007418 CP-125611 Quinone Unclear CP-122721 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007424 CP-677623 CP-919230 Oxidation - O-demethylation CP-122721 [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007422 CP-919230 CP-868352 Oxidation - Oxidationn CP-122721 [1], [2]
References
1 In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49.
2 Metabolism, pharmacokinetics, and excretion of the substance P receptor antagonist CP-122,721 in humans: structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography-tandem mass spectrometry and NMR spectroscopy

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