Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007664)
Formula
SVG example
Oxidationn
Reactant Benzotetronic acid Product 2-Keto
Reactant Info Product Info
Metabolic Enzyme Aldehyde oxidase (AOX1) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007652 Benzotetronic acid 17-noraphidicolinone Unclear Benzotetronic acid [1]
MR007651 Benzotetronic acid 18-noraphidicolinone isomers Unclear Benzotetronic acid [1]
MR007650 Benzotetronic acid 3-ketoaphidicolin Unclear Benzotetronic acid [1]
MR007666 Benzotetronic acid Cis-Diol Oxidation - Hydrolyzationn Benzotetronic acid [2]
MR007668 Benzotetronic acid RS-8359 Glucuronide Conjugation - Glucuronidation Benzotetronic acid [2]
MR007669 Benzotetronic acid Trans-Diol Oxidation - Hydrolyzationn Benzotetronic acid [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007665 2-Keto 2-Keto-ci8-dlol Oxidation - Hydrolyzationn Benzotetronic acid [2]
References
1 The mechanism of aphidicolin bioinactivation by rat liver in vitro systems. Xenobiotica. 1990 Mar;20(3):273-87.
2 Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes. Chirality. 2005 Mar;17(3):135-41.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.