Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007685)
Formula Reactant 7alpha-thiospironolactone Product 7alpha-thiomethylSpirolactone
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007684 Spironolactone 7alpha-thiospironolactone Oxidation - Deacetylation Spironolactone [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007696 7alpha-thiospironolactone Canrenone Other reaction - Elimination Spironolactone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007686 7alpha-thiomethylSpirolactone 6bate-OH-7alpha-thiomethylSpirolactone Oxidation - Hydroxylation Spironolactone [3]
MR007690 7alpha-thiomethylSpirolactone 7alpha-methylsulfinylSpirolactone Conjugation - S-methylation Spironolactone [3]
References
1 Conversion of spironolactone to 7 alpha-thiomethylspironolactone by hepatic and renal microsomes
2 Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites
3 The metabolism and biopharmaceutics of spironolactone in man

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