Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007954)
Formula Reactant Loxoprofen gel Product Loxoprofen trans-OH metabolite
Reactant Info Product Info
Metabolic Enzyme NADPH-dependent carbonyl reductase 1 (CBR1) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007959 Loxoprofen gel Loxoprofen cis-OH metabolite Reduction - Reduction Loxoprofen gel [1], [2]
MR007966 Loxoprofen gel Loxoprofen gel metabolite M14 Unclear - Unclear Loxoprofen gel [1], [2]
MR007964 Loxoprofen gel Loxoprofen gel metabolite M3 Unclear - Unclear Loxoprofen gel [1], [2]
MR007965 Loxoprofen gel Loxoprofen gel metabolite M9 Unclear - Unclear Loxoprofen gel [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007956 Loxoprofen trans-OH metabolite Loxoprofen gel metabolite M11 Unclear - Unclear Loxoprofen gel [1]
MR007957 Loxoprofen trans-OH metabolite Loxoprofen gel metabolite M12 Unclear - Unclear Loxoprofen gel [1]
MR007958 Loxoprofen trans-OH metabolite Loxoprofen gel metabolite M16 Unclear - Unclear Loxoprofen gel [1], [2]
MR007955 Loxoprofen trans-OH metabolite Loxoprofen gel metabolite M6 Unclear - Unclear Loxoprofen gel [1]
References
1 Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat
2 Exploring the metabolism of loxoprofen in liver microsomes: the role of cytochrome P450 and UDP-glucuronosyltransferase in its biotransformation. Pharmaceutics. 2018 Aug 2;10(3). pii: E112.

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