Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007964)
Formula Reactant Loxoprofen gel Product Loxoprofen gel metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007959 Loxoprofen gel Loxoprofen cis-OH metabolite Reduction - Reduction Loxoprofen gel [1], [2]
MR007966 Loxoprofen gel Loxoprofen gel metabolite M14 Unclear - Unclear Loxoprofen gel [1], [2]
MR007965 Loxoprofen gel Loxoprofen gel metabolite M9 Unclear - Unclear Loxoprofen gel [1]
MR007954 Loxoprofen gel Loxoprofen trans-OH metabolite Reduction - Reduction Loxoprofen gel [1], [2]
References
1 Identification of sulfonyl-loxoprofen as novel phase 2 conjugate in rat
2 Exploring the metabolism of loxoprofen in liver microsomes: the role of cytochrome P450 and UDP-glucuronosyltransferase in its biotransformation. Pharmaceutics. 2018 Aug 2;10(3). pii: E112.

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