Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008108)
Formula
PA
SVG example
Hydrolysis
Reactant Penicillin G Sodium Product Phenyl acetic acid
Reactant Info Product Info
Metabolic Enzyme penicillin amidase (PA) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008106 Penicillin G Sodium 6-aminopenicillanic acid Hydrolysis - Hydrolysis Penicillin G Sodium [1]
MR008103 Penicillin G Sodium Penicillin G Sodium metabolite M3 Unclear - Unclear Penicillin G Sodium [2]
MR008105 Penicillin G Sodium Penicillin G Sodium metabolite M7 Unclear - Unclear Penicillin G Sodium [2]
MR008099 Penicillin G Sodium Penicilloic acid Oxidation - Oxidation Penicillin G Sodium [2]
MR008107 Penicillin G Sodium Phenylacetyl-7-aminodeacetoxycephalosporanic acid (G-7-ADCA) Unclear - Unclear Penicillin G Sodium [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007824 Ipratropium Phenylacetic acid Hydrolysis - Hydrolysis Ipratropium [4]
MR008132 Penicillin Phenylacetic acid Unclear - Unclear Penicillin [5]
MR002019 Phenelzine Phenylacetic acid Hydrolysis - Hydrolysis Phenelzine [6]
MR005608 Sodium phenylbutyrate Phenylacetic acid Oxidation - Oxidationn Sodium phenylbutyrate [7]
MR002015 Phenethylamine Phenylacetic acid Unclear Phenelzine [6]
MR009197 3-(phenyl)propanoic acid 3-(phenyl)acetic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [8]
MR004490 3'-Hydroxyphenylacetic acid Phenylacetic acid Unclear VS-12343 [9]
MR004498 3-(phenyl)propionic acid Phenylacetic acid Unclear VS-12343 [9]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009198 3-(phenyl)acetic acid Benzoic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [8]
References
1 Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption
2 Identification of new minor metabolites of penicillin G in human serum by multiple-stage tandem mass spectrometry
3 Whole-Cell Biotransformation of Penicillin G by a Three-Enzyme Co-expression System with Engineered Deacetoxycephalosporin?C Synthase
4 Ipratropium bromide: drug metabolism and pharmacokinetics
5 Ligand-induced conformational change in penicillin acylase
6 Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review J Psychiatry Neurosci. 1992 Nov;17(5):206-14.
7 DrugBank(Pharmacology-Metabolism):Sodium phenylbutyrate
8 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
9 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium

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