Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008132)
Formula
pac
SVG example
Unclear
Reactant Penicillin Product Phenylacetic acid
Reactant Info Product Info
Metabolic Enzyme Penicillin G acylase (pac) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008130 Penicillin 6-aminopenicillanic acid Unclear - Unclear Penicillin [1], [2]
MR008131 Penicillin Penicilloic acid Unclear - Unclear Penicillin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007824 Ipratropium Phenylacetic acid Hydrolysis - Hydrolysis Ipratropium [3]
MR008108 Penicillin G Sodium Phenyl acetic acid Hydrolysis - Hydrolysis Penicillin G Sodium [4]
MR002019 Phenelzine Phenylacetic acid Hydrolysis - Hydrolysis Phenelzine [5]
MR005608 Sodium phenylbutyrate Phenylacetic acid Oxidation - Oxidationn Sodium phenylbutyrate [6]
MR002015 Phenethylamine Phenylacetic acid Unclear Phenelzine [5]
MR009197 3-(phenyl)propanoic acid 3-(phenyl)acetic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [7]
MR004490 3'-Hydroxyphenylacetic acid Phenylacetic acid Unclear VS-12343 [8]
MR004498 3-(phenyl)propionic acid Phenylacetic acid Unclear VS-12343 [8]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009198 3-(phenyl)acetic acid Benzoic acid Oxidation - Oxidation 3,4-Dihydroxycinnamic Acid [7]
References
1 Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption
2 Ligand-induced conformational change in penicillin acylase
3 Ipratropium bromide: drug metabolism and pharmacokinetics
4 A breakthrough in enzyme technology to fight penicillin resistance-industrial application of penicillin amidase
5 Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review J Psychiatry Neurosci. 1992 Nov;17(5):206-14.
6 DrugBank(Pharmacology-Metabolism):Sodium phenylbutyrate
7 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota
8 Biotransformation of two citrus flavanones by lactic acid bacteria in chemical defined medium

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