Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008149)
Formula Reactant Phytonadione Product Hydroxyvitamin K1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 4F2 (CYP4F2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008145 Phytonadione Quinone Unclear - Unclear Phytonadione [1]
MR008151 Phytonadione Vitamin K 5 Carbon Metabolite Unclear - Unclear Phytonadione [2], [3], [4], [5], [6]
MR008152 Phytonadione Vitamin K 7 Carbon Metabolite Unclear - Unclear Phytonadione [2], [3], [4], [5], [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008150 Hydroxyvitamin K1 Phylloquinone carboxylic acid metabolite Oxidation - Oxidation Phytonadione [7]
References
1 Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis
2 Metabolism of vitamin K1 (phylloquinone) in man
3 Vitamin K nutrition, metabolism, and requirements: current concepts and future research
4 Dietary reference values for vitamin K
5 Preparative isolation and characterization of the urinary aglycones of vitamin K1 (phylloquinone in man
6 Cytochrome P450-dependent catabolism of vitamin K: -hydroxylation catalyzed by human CYP4F2 and CYP4F11
7 DrugBank(Pharmacology-Metabolism):Phytonadione

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