Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008168)
Formula
SVG example
Hydroxylation
Reactant Tucatinib Product Tucatinib metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008163 Tucatinib Tucatinib metabolite M20 Oxidation - Oxidation Tucatinib [1]
MR008174 Tucatinib Tucatinib metabolite M23 Oxidation - Oxidation Tucatinib [1]
MR008171 Tucatinib Tucatinib metabolite M25 Oxidation - Oxazoline ring oxidation Tucatinib [1]
MR008173 Tucatinib Tucatinib metabolite M31 Oxidation - Dehydrogenation Tucatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008169 Tucatinib metabolite M1 Tucatinib metabolite M18 Unclear - Unclear Tucatinib [1]
MR008170 Tucatinib metabolite M1 Tucatinib metabolite M19 Unclear - Unclear Tucatinib [1]
References
1 Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

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