Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008171)
Formula
SVG example
Oxazoline ring oxidation
Reactant Tucatinib Product Tucatinib metabolite M25
Reactant Info Product Info
Metabolic Type Oxidation - Oxazoline ring oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008168 Tucatinib Tucatinib metabolite M1 Oxidation - Hydroxylation Tucatinib [1]
MR008163 Tucatinib Tucatinib metabolite M20 Oxidation - Oxidation Tucatinib [1]
MR008174 Tucatinib Tucatinib metabolite M23 Oxidation - Oxidation Tucatinib [1]
MR008173 Tucatinib Tucatinib metabolite M31 Oxidation - Dehydrogenation Tucatinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008172 Tucatinib metabolite M25 Tucatinib metabolite M19 Unclear - Unclear Tucatinib [1]
References
1 Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

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