Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR008536)
Formula	Hydrolysis
	Reactant	TH-302		Product	TH-302 metabolite RM3
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008537	TH-302	TH-302 metabolite RM12	Hydrolysis - Hydrolysis	TH-302	[1], [2]
MR008526	TH-302	TH-302 metabolite RM9	Conjugation - Glutathione conjugation	TH-302	[1]

References
1	Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats
2	Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.