Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008526)
Formula
SVG example
Glutathione conjugation
Reactant TH-302 Product TH-302 metabolite RM9
Reactant Info Product Info
Metabolic Type Conjugation - Glutathione conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008537 TH-302 TH-302 metabolite RM12 Hydrolysis - Hydrolysis TH-302 [1], [2]
MR008536 TH-302 TH-302 metabolite RM3 Hydrolysis - Hydrolysis TH-302 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008535 TH-302 metabolite RM9 TH-302 metabolite RM10 Hydrolysis - Hydrolysis TH-302 [1]
MR008534 TH-302 metabolite RM9 TH-302 metabolite RM5 Hydrolysis - Hydrolysis TH-302 [1]
MR008533 TH-302 metabolite RM9 TH-302 metabolite RM6 Oxidation - Oxidation TH-302 [1]
MR008527 TH-302 metabolite RM9 TH-302 metabolite RM7 Hydrolysis - Hydrolysis TH-302 [1]
References
1 Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats
2 Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys

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