Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008874)
Formula
CYP3A5 ...
SVG example
7-hydroxylation
Reactant Lasofoxifene Product 7-hydroxy-lasofoxifene (7-OHLAS)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 7-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008875 Lasofoxifene 5-hydroxy-lasofoxifene (5-OHLAS) Oxidation - 5-hydroxylation Lasofoxifene [1]
MR008877 Lasofoxifene Lasofoxifene metabolite M11 Conjugation - Sulfate conjugation Lasofoxifene [2]
MR008878 Lasofoxifene Lasofoxifene metabolite M13 Unclear - Unclear Lasofoxifene [2]
MR008872 Lasofoxifene Lasofoxifene metabolite M15 Unclear - Unclear Lasofoxifene [2]
MR008876 Lasofoxifene Lasofoxifene metabolite M7 Unclear - Unclear Lasofoxifene [2]
References
1 Disposition of lasofoxifene, a next-generation selective estrogen receptor modulator, in healthy male subjects
2 Metabolism, distribution, and excretion of a next generation selective estrogen receptor modulator, lasofoxifene, in rats and monkeys

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