Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009092)
Formula
SVG example
Hydroxylation
Reactant Fidarestat Metabolite F1 Product Fidarestat Metabolite F2
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009091 Fidarestat Fidarestat Metabolite F1 Multi-steps Reaction - Oxidation; deamination Fidarestat [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009096 Fidarestat Metabolite F1 Fidarestat Metabolite F10 Conjugation - Glycosylation Fidarestat [1]
MR009094 Fidarestat Metabolite F1 Fidarestat Metabolite F12 Conjugation - Glucuronidation Fidarestat [1]
MR009095 Fidarestat Metabolite F1 Fidarestat Metabolite F7 Conjugation - Acetylation Fidarestat [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009093 Fidarestat Metabolite F2 Fidarestat Metabolite F13 Conjugation - Glucuronidation Fidarestat [1]
References
1 Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites
2 Plasma protein binding, pharmacokinetics, tissue distribution and CYP450 biotransformation studies of fidarestat by ultra high performance liquid chromatography-high resolution mass spectrometry

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