Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009227)
Formula
SVG example
Unclear
Reactant Hydroxy-ebastine Product Ebastine Metabolite M-5a
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009218 Ebastine Hydroxy-ebastine Oxidation - Hydroxylation Ebastine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009219 Hydroxy-ebastine Carebastine Unclear - Unclear Ebastine [2], [1]
MR009222 Hydroxy-ebastine Ebastine Metabolite M-4 Conjugation - Mono-methylation Ebastine [3]
References
1 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.
2 Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys
3 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry

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