Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009219)
Formula
CYP
SVG example
Unclear
Reactant Hydroxy-ebastine Product Carebastine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009218 Ebastine Hydroxy-ebastine Oxidation - Hydroxylation Ebastine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009222 Hydroxy-ebastine Ebastine Metabolite M-4 Conjugation - Mono-methylation Ebastine [2]
MR009227 Hydroxy-ebastine Ebastine Metabolite M-5a Unclear - Unclear Ebastine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009221 Carebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [1]
MR009220 Carebastine Ebastine Metabolite M-3 Unclear - Unclear Ebastine [3], [2]
References
1 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.
2 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry
3 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

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