Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009517)
Formula	N-demethylation
	Reactant	Regorafenib M2	Product	Regorafenib M5
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - N-demethylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009514	Regorafenib	Regorafenib M2	Oxidation - N-oxidation	Regorafenib	[1], [2]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009515	Regorafenib M2	Regorafenib M1	Oxidation - Methylhydroxylation	Regorafenib	[2]
MR009518	Regorafenib M2	Regorafenib M8	Conjugation - Glucuronidation	Regorafenib	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009516	Regorafenib M1	Regorafenib M5	Oxidation - Demethylation	Regorafenib	[2]

References
1	Quantification of cobimetinib, cabozantinib, dabrafenib, niraparib, olaparib, vemurafenib, regorafenib and its metabolite regorafenib M2 in human plasma by UPLC-MS/MS
2	Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

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