Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009514)
Formula	CYP3A4 N-oxidation
	Reactant	Regorafenib	Product	Regorafenib M2
	Reactant	Reactant Info	Product	Product Info
Metabolic Enzyme	Cytochrome P450 3A4 (CYP3A4)				DME Info
Metabolic Type	Oxidation - N-oxidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009519	Regorafenib	Regorafenib M3	Oxidation - Hydroxylation	Regorafenib	[1]
MR009524	Regorafenib	Regorafenib M7	Conjugation - Glucuronidation	Regorafenib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009515	Regorafenib M2	Regorafenib M1	Oxidation - Methylhydroxylation	Regorafenib	[1]
MR009517	Regorafenib M2	Regorafenib M5	Oxidation - N-demethylation	Regorafenib	[2], [1]
MR009518	Regorafenib M2	Regorafenib M8	Conjugation - Glucuronidation	Regorafenib	[1]

References
1	Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects
2	Quantification of cobimetinib, cabozantinib, dabrafenib, niraparib, olaparib, vemurafenib, regorafenib and its metabolite regorafenib M2 in human plasma by UPLC-MS/MS

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.