Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009520)
Formula Reactant Regorafenib M3 Product Regorafenib M1
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - N-oxidation; methylhydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009519 Regorafenib Regorafenib M3 Oxidation - Hydroxylation Regorafenib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009521 Regorafenib M3 Regorafenib M4 Oxidation - N-demethylation Regorafenib [1]
MR009523 Regorafenib M3 Regorafenib M6 Oxidation - Oxidation Regorafenib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009515 Regorafenib M2 Regorafenib M1 Oxidation - Methylhydroxylation Regorafenib [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009516 Regorafenib M1 Regorafenib M5 Oxidation - Demethylation Regorafenib [1]
References
1 Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

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