Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009519)
Formula Reactant Regorafenib Product Regorafenib M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009514 Regorafenib Regorafenib M2 Oxidation - N-oxidation Regorafenib [1], [2]
MR009524 Regorafenib Regorafenib M7 Conjugation - Glucuronidation Regorafenib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009520 Regorafenib M3 Regorafenib M1 Multi-steps Reaction - N-oxidation; methylhydroxylation Regorafenib [2]
MR009521 Regorafenib M3 Regorafenib M4 Oxidation - N-demethylation Regorafenib [2]
MR009523 Regorafenib M3 Regorafenib M6 Oxidation - Oxidation Regorafenib [2]
References
1 Quantification of cobimetinib, cabozantinib, dabrafenib, niraparib, olaparib, vemurafenib, regorafenib and its metabolite regorafenib M2 in human plasma by UPLC-MS/MS
2 Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects

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