Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009587)
Formula
SVG example
N-demethylation
Reactant Ortho-Hydroxyrosiglitazone Product N-Desmethyl-ortho-hydroxy rosiglitazone
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009586 Rosiglitazone Ortho-Hydroxyrosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009589 Ortho-Hydroxyrosiglitazone Ortho-O-Glucuronide rosiglitazone Conjugation - Glucuronidation Rosiglitazone [1]
MR009588 Ortho-Hydroxyrosiglitazone Ortho-O-Sulfate rosiglitazone Oxidation - Sulfonation Rosiglitazone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009579 N-Desmethylrosiglitazone N-Desmethyl-ortho-hydroxy rosiglitazone Oxidation - Hydroxylation Rosiglitazone [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009580 N-Desmethyl-ortho-hydroxy rosiglitazone N-Desmethyl-ortho-O-sulfate rosiglitazone Oxidation - Sulfonation Rosiglitazone [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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