Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009733)
Formula
SVG example
Unclear
Reactant Motesanib Product Motesanib Mx
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009731 Motesanib Motesanib M1 Conjugation - Glucuronidation Motesanib [1]
MR009732 Motesanib Motesanib M3 Unclear - Unclear Motesanib [1]
MR009726 Motesanib Motesanib M4 Unclear - Unclear Motesanib [1], [2]
MR009723 Motesanib Motesanib M5 Oxidation - Hydroxylation Motesanib [1]
MR009729 Motesanib Motesanib Ma Unclear - Unclear Motesanib [1]
MR009730 Motesanib Motesanib Mb Unclear - Unclear Motesanib [1]
MR009727 Motesanib Motesanib Mv Unclear - Unclear Motesanib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001241 Isoniazid Isonicotinic acid Unclear Isoniazid [3]
MR001233 Acetylisoniazid Isonicotinic acid Unclear Isoniazid [3]
MR013188 isonicotinyl-formamide Isonicotinic acid Unclear Piroximone [4]
References
1 In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans
2 Population pharmacokinetic modeling of motesanib and its active metabolite, M4, in cancer patients
3 Exploration of inhibition potential of isoniazid and its metabolites towards CYP2E1 in human liver microsomes through LC-MS/MS analysis J Pharm Biomed Anal. 2021 Sep 5;203:114223. doi: 10.1016/j.jpba.2021.114223.
4 Metabolism and pharmacokinetics of the cardiotonic agent piroximone and of its major metabolite in dog

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