Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009846)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Alprazolam Product 4-hydroxyalprazolam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A43 (CYP3A43) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009844 Alprazolam 5-N-O?alprazolam Unclear - Unclear Alprazolam [1]
MR009848 Alprazolam Alpha-hydroxyalprazolam Unclear - Unclear Alprazolam [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009847 4-hydroxyalprazolam Benzophenone Unclear - Unclear Alprazolam [3]
References
1 Changes in Alprazolam Metabolism by CYP3A43 Mutants
2 Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite
3 In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

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