Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009947)
Formula
SVG example
Unclear
Reactant 4-Hydroxycyclophosphamide Product 4-Ketocyclophosphamide
Reactant Info Product Info
Metabolic Enzyme Aldehyde dehydrogenase (ALDH) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012897 Cyclobenzaprine 4-Hydroxycyclophosphamide Oxidation - 4-hydroxylation Cyclobenzaprine [1], [2]
MR009942 Cyclophosphamide 4-Hydroxycyclophosphamide Unclear - Unclear Cyclophosphamide [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009943 4-Hydroxycyclophosphamide Aldophosphamide Unclear - Unclear Cyclophosphamide [2]
MR012898 4-Hydroxycyclophosphamide Aldophosphamide Unclear Cyclobenzaprine [2]
References
1 The KEGG resource for deciphering the genome
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.