Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012898)
Formula
SVG example
Reactant 4-Hydroxycyclophosphamide Product Aldophosphamide
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012897 Cyclobenzaprine 4-Hydroxycyclophosphamide Oxidation - 4-hydroxylation Cyclobenzaprine [1], [2]
MR009942 Cyclophosphamide 4-Hydroxycyclophosphamide Unclear - Unclear Cyclophosphamide [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009947 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear - Unclear Cyclophosphamide [2]
MR012906 4-Hydroxycyclophosphamide 4-Ketocyclophosphamide Unclear Cyclobenzaprine [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009946 Aldophosphamide Acrolein Unclear - Unclear Cyclophosphamide [2]
MR012901 Aldophosphamide Acrolein Unclear Cyclobenzaprine [1]
MR012905 Aldophosphamide Alcophosphamide Unclear Cyclobenzaprine [4]
MR009945 Aldophosphamide Carboxyphosphamide Unclear - Unclear Cyclophosphamide [2]
MR012903 Aldophosphamide Carboxyphosphamide Unclear Cyclobenzaprine [4]
MR009944 Aldophosphamide Phosphamide mustard Unclear - Unclear Cyclophosphamide [2]
MR012899 Aldophosphamide Phosphoramide Mustard Unclear Cyclobenzaprine [5]
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References
1 The KEGG resource for deciphering the genome
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Aprepitant inhibits cyclophosphamide bioactivation and thiotepa metabolism
4 U. S. FDA Label -Cyclobenzaprine
5 DrugBank(Pharmacology-Metabolism):Cyclobenzaprine

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