Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010794)
Formula Reactant Naloxone Product Naloxone Metabolite M10
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010797 Naloxone Naloxol Reduction - 6-ketoreduction Naloxone [1]
MR010796 Naloxone Naloxone 3-Glucuronide Conjugation - Glucuronidation Naloxone [2]
MR010785 Naloxone Naloxone Metabolite M2 Unclear - Unclear Naloxone [3]
MR010789 Naloxone Naloxone Metabolite M21 Unclear - Unclear Naloxone [3]
MR010791 Naloxone Naloxone Metabolite M23 Unclear - Unclear Naloxone [3]
MR010795 Naloxone Naloxone Metabolite M26 Unclear - Unclear Naloxone [3]
MR010793 Naloxone Naloxone Metabolite M31 Unclear - Unclear Naloxone [3]
MR010787 Naloxone Naloxone Metabolite M4 Unclear - Unclear Naloxone [3]
MR010792 Naloxone Naloxone Metabolite M5 Unclear - Unclear Naloxone [3]
MR010790 Naloxone Naloxone Metabolite M7 Unclear - Unclear Naloxone [3], [4]
References
1 Metabolites of naloxone in human urine
2 Effect of naloxone-3-glucuronide and N-methylnaloxone on the motility of the isolated rat colon after morphine
3 Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
4 PBPK Modeling as a Tool for Predicting and Understanding Intestinal Metabolism of Uridine 5'-Diphospho-glucuronosyltransferase Substrates

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