Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010979)
Formula
SVG example
Hydroxylation
Reactant Exjade Product Exjade Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A (CYP1A) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010978 Exjade Exjade Metabolite M1 Oxidation - Hydroxylation Exjade [1]
MR010977 Exjade Exjade Metabolite M3 Conjugation - O-glucuronidation Exjade [1]
MR010980 Exjade Exjade Metabolite M4 Oxidation - Hydroxylation Exjade [1]
MR010981 Exjade Exjade Metabolite M6 Conjugation - O-glucuronidation Exjade [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000756 Deferasirox Deferasirox metabolite M2 Oxidation - Hydroxylation Deferasirox [2], [1]
References
1 Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats Drug Metab Dispos. 2008 Dec;36(12):2523-38. doi: 10.1124/dmd.108.022962.
2 Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state Drug Metab Dispos. 2010 May;38(5):808-16. doi: 10.1124/dmd.109.030833.

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