Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010980)
Formula
SVG example
Hydroxylation
Reactant Exjade Product Exjade Metabolite M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A (CYP1A) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010978 Exjade Exjade Metabolite M1 Oxidation - Hydroxylation Exjade [1]
MR010979 Exjade Exjade Metabolite M2 Oxidation - Hydroxylation Exjade [1]
MR010977 Exjade Exjade Metabolite M3 Conjugation - O-glucuronidation Exjade [1]
MR010981 Exjade Exjade Metabolite M6 Conjugation - O-glucuronidation Exjade [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000758 Deferasirox Deferasirox metabolite M4 Conjugation - O-Glucuronidation Deferasirox [2]
References
1 Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats Drug Metab Dispos. 2008 Dec;36(12):2523-38. doi: 10.1124/dmd.108.022962.
2 Kinetics of deamination of 5-aza-2'-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside Biochem Pharmacol. 1983 Apr 1;32(7):1327-8. doi: 10.1016/0006-2952(83)90293-9.

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