Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011447)
Formula Reactant Guanfacine Product Guanfacine dihydro-diol
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Epoxidation; hydratuon
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010578 Guanfacine 3-Hydroxyguanfacine Oxidation - Oxidation Guanfacine [1]
MR010585 Guanfacine Guanfacine Metabolite M1 Multi-steps Reaction - Epoxidation; hydration Guanfacine [1]
MR010584 Guanfacine Guanfacine Metabolite M4,5,7,8 Conjugation - Glucuronidation Guanfacine [1]
MR011446 Guanfacine Guanfacine Metabolite M4,M5,M7,M8 Conjugation - Glucuronidation Guanfacine [1]
MR010581 Guanfacine Guanfacine Metabolite M6 Oxidation - Oxidation Guanfacine [1]
MR011448 Guanfacine HydroxyGuanfacine Unclear - Unclear Guanfacine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005065 Guanfacine hydrochloride Guanfacine dihydro-diol Multi-steps Reaction - Epoxidation; hydration Guanfacine hydrochloride [1]
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets

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