Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010578)
Formula
SVG example
Oxidation
Reactant Guanfacine Product 3-Hydroxyguanfacine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011447 Guanfacine Guanfacine dihydro-diol Multi-steps Reaction - Epoxidation; hydratuon Guanfacine [1]
MR010585 Guanfacine Guanfacine Metabolite M1 Multi-steps Reaction - Epoxidation; hydration Guanfacine [1]
MR010584 Guanfacine Guanfacine Metabolite M4,5,7,8 Conjugation - Glucuronidation Guanfacine [1]
MR011446 Guanfacine Guanfacine Metabolite M4,M5,M7,M8 Conjugation - Glucuronidation Guanfacine [1]
MR010581 Guanfacine Guanfacine Metabolite M6 Oxidation - Oxidation Guanfacine [1]
MR011448 Guanfacine HydroxyGuanfacine Unclear - Unclear Guanfacine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005062 Guanfacine hydrochloride 3-hydroxyguanfacine Oxidation - Oxidationn Guanfacine hydrochloride [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011444 3-hydroxyGuanfacine Glucuronide of hydroxy-Guanfacine Conjugation - Glucuronidation Guanfacine [1]
MR005064 3-hydroxyguanfacine Guanfacine 3-glucuronide Conjugation - O-glucuronidation Guanfacine hydrochloride [4]
MR005063 3-hydroxyguanfacine Guanfacine 3-sulfate Conjugation - Sulfation Guanfacine hydrochloride [4]
MR010579 3-Hydroxyguanfacine Guanfacine Metabolite M2 Conjugation - Glucuronidation Guanfacine [1]
MR010580 3-Hydroxyguanfacine Guanfacine Metabolite M3 Conjugation - Sulfation Guanfacine [1]
MR011445 3-hydroxyGuanfacine Sulfate of hydroxy-Guanfacine Conjugation - Sulfation Guanfacine [1]
⏷ Show the Full List of MR
References
1 Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended-release tablets
2 Determination of 3-hydroxy-guanfacine in biological fluids by electron-capture gas-liquid chromatography
3 Pharmacokinetics and metabolism of guanfacine in man: a review
4 DrugBank(Pharmacology-Metabolism):Guanfacine hydrochloride

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