Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012671)
Formula
SVG example
Hydroxylation
Reactant N-desmethyl ruboxistaurin Product Ruboxistaurin metabolite 5
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012670 LY-333531 N-desmethyl ruboxistaurin Oxidation - N-demethylation LY-333531 [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012673 Ruboxistaurin metabolite 3 Ruboxistaurin metabolite 5 Oxidation - N-demethylation LY-333531 [3]
References
1 The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450. Drug Metab Dispos. 2002 Sep;30(9):957-61.
2 Effects of chronic renal failure on the pharmacokinetics of ruboxistaurin and its active metabolite 338522
3 Disposition of [14C]ruboxistaurin in humans

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