Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012846)
Formula
UGT1A9 ...
SVG example
Reactant Dabigatran Product Dabigatran Acylglucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012837 Dabigatran Dabigatran M400 Unclear Dabigatran [1]
MR012839 Dabigatran Dabigatran metabolite M324 Unclear Dabigatran [1]
MR012832 Dabigatran Dabigatran metabolite M355 Unclear Dabigatran [1]
MR012829 Dabigatran Dabigatran metabolite M486(1) Unclear Dabigatran [1]
MR012845 Dabigatran Dabigatran metabolite M488 Unclear Dabigatran [1]
MR012841 Dabigatran Dabigatran metabolite M648 Unclear Dabigatran [1]
MR012838 Dabigatran Dabigatran metabolite M1 Unclear Dabigatran [1]
MR013418 Dabigatran BIBR1151/M324 Hydrolysis - Hydrolysis Dabigatran etexilate [2]
MR013421 Dabigatran Dabigatran 1-O-acylglucuronide metabolite Conjugation - Glucuronidation Dabigatran etexilate [2]
MR013411 Dabigatran Dabigatran M355 Hydrolysis - Hydrolysis Dabigatran etexilate [2]
MR013420 Dabigatran Dabigatran M400 Hydrolysis - Hydrolysis Dabigatran etexilate [2]
MR013416 Dabigatran Dabigatran M486 Oxidation - Oxidationn Dabigatran etexilate [2]
MR013427 Dabigatran Dabigatran 2-O-acylglucuronide metabolite Unclear Dabigatran etexilate [2]
MR013426 Dabigatran Dabigatran 3-O-acylglucuronide metabolite Unclear Dabigatran etexilate [2]
MR013425 Dabigatran Dabigatran 4-O-acylglucuronide metabolite Unclear Dabigatran etexilate [2]
MR013423 Dabigatran Dabigatran M486-2 Unclear Dabigatran etexilate [2]
MR013424 Dabigatran Dabigatran M690 Unclear Dabigatran etexilate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011251 Trihydroxyanisodine Anisodine Metabolite M8 Unclear - Unclear Anisodine [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011255 Anisodine Metabolite M8 Anisodine Metabolite M9 Unclear - Unclear Anisodine [3]
References
1 The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
2 DrugBank(Pharmacology-Metabolism): Dabigatran etexilate
3 Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry

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