Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012908)
Formula
SVG example
Reactant Cyclobenzaprine Product Chloroacetaldehyde
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A7 (CYP3A7) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012897 Cyclobenzaprine 4-Hydroxycyclophosphamide Oxidation - 4-hydroxylation Cyclobenzaprine [1], [2]
MR012907 Cyclobenzaprine Dechloroethyl cyclophosphamide Unclear Cyclobenzaprine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004660 Ifosfamide Chloroacetaldehyde Unclear Ifosfamide [1], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004661 Chloroacetaldehyde 2-chloroethanol Oxidation - Oxidationn Ifosfamide [5]
References
1 The KEGG resource for deciphering the genome
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 U. S. FDA Label -Cyclobenzaprine
4 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity
5 DrugBank(Pharmacology-Metabolism):Ifosfamide

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