Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012947)
Formula Reactant PCI-48303 (M26) Product ICGS
Reactant Info Product Info
Metabolic Enzyme Gamma-glutamyltranspeptidase 5 (GGT5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012946 Ibrutinib PCI-48303 (M26) Conjugation - Glutathione conjugation Ibrutinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012948 ICGS ICYS Unclear Ibrutinib [2]
References
1 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
2 Extrahepatic metabolism of ibrutinib

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