Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012970)
Formula Reactant GS-563117 Product Idelalisib Metabolite M19
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012969 Idelalisib GS-563117 Unclear Idelalisib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012974 GS-563117 Idelalisib Metabolite M20 Unclear Idelalisib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012971 Idelalisib Metabolite M19 Idelalisib Metabolite M16 Unclear Idelalisib [2]
MR012976 Idelalisib Metabolite M19 Idelalisib Metabolite M17 Unclear Idelalisib [2]
References
1 Clinical drug interaction profile of idelalisib in healthy subjects
2 Identification of Novel Pathways in Idelalisib Metabolism and Bioactivation

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