Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013100)
Formula Reactant ABT-333 Metabolite M1 Product ABT-333 Metabolite M4
Reactant Info Product Info
Metabolic Enzyme DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013099 ABT-333 ABT-333 Metabolite M1 Oxidation - Oxidation ABT-333 [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013110 ABT-333 Metabolite M1 ABT-333 Metabolite M11 Oxidation - Oxidation ABT-333 [1]
MR013108 ABT-333 Metabolite M1 ABT-333 Metabolite M2 Conjugation - Conjugation ABT-333 [1]
MR013105 ABT-333 Metabolite M1 ABT-333 Metabolite M3 Unclear - Unclear ABT-333 [1]
MR013106 ABT-333 Metabolite M1 ABT-333 Metabolite M9 Reduction - Reduction ABT-333 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013101 ABT-333 Metabolite M4 ABT-333 Metabolite M5 Oxidation - Oxidation ABT-333 [1]
References
1 Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1139-47.
2 Clinical Pharmacokinetics of Dasabuvir

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