Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013125)
Formula	Deacetylation
	Reactant	Trametinib	Product	Trametinib Metabolite M1
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Oxidation - Deacetylation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013127	Trametinib	Trametinib Metabolite M3	Oxidation - Hydroxylation	Trametinib	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR013126	Trametinib Metabolite M1	Trametinib Metabolite M2	Multi-steps Reaction - Deacetylation; N-glucuronidation	Trametinib	[1]

References
1	Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers

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