Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR5314)
Drug Name
Trametinib
Synonyms
GSK 1120212; GSK-1120212; GSK1120212; JTP 74057; JTP-74057; Mekinist; Trametinib (GSK1120212); Trametinib (GSK1120212JTP 74057); Trametinib (MEK inhibitor); 33E86K87QN; A1-01871; AK174783; CHEBI:75998; UNII-33E86K87QN
Indication Melanoma [ICD11: 2C30] Approved [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 615.4 Topological Polar Surface Area 102
Heavy Atom Count 37 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
11707110
ChEBI ID
CHEBI:75998
CAS Number
871700-17-3
TTD Drug ID
D04XVN
Formula
C26H23FIN5O4
Canonical SMILES
CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
InChI
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChIKey
LIRYPHYGHXZJBZ-UHFFFAOYSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Trametinib Metabolite M1 DM016222
59717278
Oxidation - Deacetylation 1 [2]
Trametinib Metabolite M3 DM016540
118796491
Oxidation - Hydroxylation 1 [3]
Trametinib Metabolite M2 DM015351
1190257
Multi-steps Reaction - Deacetylation; N-glucuronidation 2 [3]
Trametinib Metabolite M4 DM018747 N. A. Multi-steps Reaction - Deacetylation, hydroxylation,glucuronidation 2 [3]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR013125 Trametinib Trametinib Metabolite M1 Oxidation - Deacetylation Unclear [2]
MR013127 Trametinib Trametinib Metabolite M3 Oxidation - Hydroxylation Unclear [3]
MR013126 Trametinib Metabolite M1 Trametinib Metabolite M2 Multi-steps Reaction - Deacetylation; N-glucuronidation Unclear [3]
MR013128 Trametinib Metabolite M2 Trametinib Metabolite M4 Multi-steps Reaction - Deacetylation, hydroxylation,glucuronidation Unclear [3]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
Cytochrome P450 3A (CYP3A) DMEN065 . Not Available Not Available [2]
References
1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6495).
2 Pharmacokinetic Interaction Between the MEK1/MEK2 Inhibitor Trametinib and Oral Contraceptives Containing Norethindrone and Ethinyl Estradiol in Female Patients With Solid Tumors
3 Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers

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