Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013198)
Formula Reactant Ponesimod Product Ponesimod M12 Metabolite (ACT-204426)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2J2 (CYP2J2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info
Cytochrome P450 4F12 (CYP4F12) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013208 Ponesimod Ponesimod M13 Metabolite Oxidation - Oxidationn Ponesimod [1]
MR013204 Ponesimod Ponesimod M27 Metabolite Oxidation - Oxidationn Ponesimod [1]
MR013203 Ponesimod Ponesimod M32 Metabolite Oxidation - Dealkylation Ponesimod [1]
MR013207 Ponesimod Ponesimod M5 Metabolite Conjugation - Sulfation Ponesimod [1]
MR013206 Ponesimod Ponesimod M6 Metabolite Reduction - Reduction Ponesimod [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013199 Ponesimod M12 Metabolite (ACT-204426) Ponesimod M13 Metabolite (ACT-338275) Multi-steps Reaction - Hydrolysis; oxidation Ponesimod [1]
MR013202 Ponesimod M12 Metabolite (ACT-204426) Ponesimod M32 Metabolite Oxidation - Dealkylation Ponesimod [1]
References
1 Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans

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