Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013202)
Formula Reactant Ponesimod M12 Metabolite (ACT-204426) Product Ponesimod M32 Metabolite
Reactant Info Product Info
Metabolic Type Oxidation - Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013198 Ponesimod Ponesimod M12 Metabolite (ACT-204426) Oxidation - Oxidationn Ponesimod [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013199 Ponesimod M12 Metabolite (ACT-204426) Ponesimod M13 Metabolite (ACT-338275) Multi-steps Reaction - Hydrolysis; oxidation Ponesimod [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013203 Ponesimod Ponesimod M32 Metabolite Oxidation - Dealkylation Ponesimod [1]
MR013200 Ponesimod M13 Metabolite (ACT-338275) Ponesimod M32 Metabolite Oxidation - Dealkylation Ponesimod [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013201 Ponesimod M32 Metabolite Ponesimod M48 Metabolite Multi-steps Reaction - Oxidationn; reduction Ponesimod [1]
References
1 Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans

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