Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013247)
Formula
SVG example
Reactant UK-51,060 Product UK-215,364
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013246 Voriconazole N-Oxide Metabolite UK-51,060 Unclear Voriconazole [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010837 Efinaconazole Efinaconazole H3 Unclear - Unclear Efinaconazole [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013248 UK-215,364 Voriconazole O-glucuronide derivative (1) Conjugation - Glucuronidation Voriconazole [1], [2]
MR013249 UK-215,364 Voriconazole O-glucuronide derivative (2) Conjugation - Glucuronidation Voriconazole [1], [2]
References
1 The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human
2 Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6.
3 Safety and pharmacokinetics of efinaconazole 10% solution in healthy volunteers and patients with severe onychomycosis

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