Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013291)
Formula
SVG example
Oxidationn
Reactant Zaleplon Product 5-Oxo-zaleplon
Reactant Info Product Info
Metabolic Enzyme Aldehyde oxidase (AOX1) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013293 Zaleplon N-Desesethylzaleplon Oxidation - N-dealkylation Zaleplon [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013292 5-Oxo-zaleplon N-desethyl-5-oxo-ZAL (M1) Oxidation - N-dealkylation Zaleplon [1], [2], [3]
References
1 Variability of Zaleplon 5-Oxidase Activity in Mice and Humans, and Inhibition by Raloxifene
2 Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica. 2002 Oct;32(10):835-47.
3 Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser-induced fluorescence detection and liquid chromatography-mass spectrometry

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