Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013319)
Formula
SVG example
Reactant 4-Hydroxyestradiol Product 4-methoxyestradiol
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004105 Conjugated estrogens 4-Hydroxyestradiol Oxidation - Hydrolyzationn Conjugated estrogens [1]
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [2]
MR013316 4-hydroxyestrone 4-Hydroxyestradiol Unclear E-3A [3]
MR002626 Estradiol 4-hydroxyestradiol Unclear Estradiol acetate [3]
MR002649 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol cypionate [3]
MR002672 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol valerate [3]
MR002643 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol acetate [4]
MR002666 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol cypionate [4]
MR002689 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol valerate [4]
⏷ Show the Full List of MR
References
1 Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism
2 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
3 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
4 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.

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