Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013318)
Formula
SVG example
Reactant E-3A Product 4-Hydroxyestradiol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1B1 (CYP1B1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013329 E-3A 17-beta-estradiol 3-sulfate-17-(beta-D-glucuronide) Unclear E-3A [1]
MR013326 E-3A 17-beta-Estradiol glucuronide Unclear E-3A [2], [3]
MR013324 E-3A 17-beta-Estradiol-3-glucuronide Unclear E-3A [1]
MR013327 E-3A 17alpha-Estradiol-3-glucuronide Unclear E-3A [1]
MR013308 E-3A 17beta-Estradiol-3,17-beta-sulfate Unclear E-3A [4]
MR013313 E-3A 2-hydroxyestrone Oxidation - 2-hydroxylation E-3A [5]
MR013325 E-3A 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) Unclear E-3A [2]
MR013323 E-3A 2-Methoxyestrone 3-glucuronide Unclear E-3A [5]
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [6]
MR013328 E-3A Estradiol-17alpha 3-D-glucuronoside Unclear E-3A [1]
MR013322 E-3A Estradiol-17beta 3-sulfate Unclear E-3A [7]
MR013320 E-3A Estrone Unclear E-3A [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004105 Conjugated estrogens 4-Hydroxyestradiol Oxidation - Hydrolyzationn Conjugated estrogens [8]
MR013316 4-hydroxyestrone 4-Hydroxyestradiol Unclear E-3A [9]
MR002626 Estradiol 4-hydroxyestradiol Unclear Estradiol acetate [9]
MR002649 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol cypionate [9]
MR002672 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol valerate [9]
MR002643 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol acetate [10]
MR002666 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol cypionate [10]
MR002689 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol valerate [10]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013319 4-Hydroxyestradiol 4-methoxyestradiol Unclear E-3A [6]
MR002642 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol acetate [9]
MR002665 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol cypionate [9]
MR002688 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol valerate [9]
References
1 DrugBank(Pharmacology-Metabolism):E-3A
2 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
3 Profiling endogenous serum estrogen and estrogen-glucuronides by liquid chromatography-tandem mass spectrometry Anal Chem. 2009 Dec 15;81(24):10143-8. doi: 10.1021/ac9019126.
4 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
5 DrugBank(Pharmacology-Metabolism)Estradiol acetate
6 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
7 FOODB:E-3A
8 Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism
9 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
10 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.

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